Health Condition 1: S061- Traumatic cerebral edema
Conditions
Interventions
Control Intervention1: Mannitol and Hypertonic Saline: Patients will be randomly allocated into two groups using opaque sealed envelopes (Group A - 3% Hypertonic Saline treatment and Group B - 20% Ma
Sponsors
Nil Applied for
Eligibility
Inclusion criteria
Inclusion criteria: Pediatric patients admitted to Neurosurgery ICU and planned for initial conservative management at admission. GCS Patients presenting within 24 hours of injury Age 0-18 years
Exclusion criteria
Exclusion criteria: Patients with polytrauma (Blunt trauma chest, blunt trauma abdomen, long bone fracture or spine injury) Patients with shock, sepsis, chronic kidney disease, steroid, antiinflammatory drugs or diabetes mellitus History of encephalitis, CNS vasculitis, meningitis, brain abscess, brain tumor or cranial surgery Past history of head injury Patient requiring primary surgery for post-traumatic intracranial hematomas at admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. â?¢ Comparing effectiveness of Hypertonic Saline and Mannitol will give us the level 1 evidence of superiority between the two to be used after TBI in pediatric population 2. â?¢ After understanding the pathophysiology of cerebral edema with the help of the biomarkers and genetic polymorphism, development of anti-edema measures can be done. Timepoint: 2Years | — |
Secondary
| Measure | Time frame |
|---|---|
| After the development of anti-edema measures, patients can get early treatment and can be prevented from getting worsened.Timepoint: 2 Years | — |
Countries
India
Contacts
Public ContactKaveri Sharma
Neurosurgeon (AIIMS, New Delhi)
Outcome results
None listed