Reduction in blood pressure to laryngoscopy and tracheal intubation:A comparison of effect of preoperative administration of intravenous paracetamol versus narcotic medication.

Attenuation of haemodynamic response to laryngoscopy and tracheal intubation: A comparison of effect of preoperative administration of intravenous paracetamol versus fentanyl-A double blind randomised control trial.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/02/031088

Enrollment

Registered

2021-02-08

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: G998- Other specified disorders of nervous system in diseases classified elsewhere

Interventions

Intervention1: INTUBATION RESPONSE: INJECTION FENTANYL INTRAVENOUS 2 MICROGRAMS PER KG BODY WEIGHT 15 MINUTES BEFORE INTUBATION Control Intervention1: INTUBATION RESPONSE: INJECTION PARACETAMOL 15MG/K

Eligibility

Inclusion criteria

Inclusion criteria: a)Patients aged between 18-65 years of both gender. b)Patients belonging to American Society of Anesthesiologists Physical Status 1 and 2. c)Patients undergoing surgeries under general endotracheal anaesthesia. d)Patients who are willing to give written informed consent to participate in the study.

Exclusion criteria

Exclusion criteria: ï?·Not willing to give written informed consent. ï?·Weighed 100kg. ï?·Body mass index(BMI) >30kg/m2. ï?·Pregnant and Lactating women. ï?·Cardiovascular or respiratory disease. ï?·Renal, liver, or haematological disorders. ï?·History of cerebrovascular or psychiatric disease. ï?·At high risk of aspiration or regurgitation. ï?·Anticipated difficult intubation. ï?·Diabetic patients with autonomic dysfunction. ï?·History of opium addiction or hypersensitivity. ï?·Known contraindications to use of paracetamol and itâ??s hypersensitivity. ï?·Continuing consumption of any drugs affecting cardiovascular system.

Design outcomes

Primary

Measure	Time frame
To compare the effects of intravenous paracetamol to intravenous fentanyl on attenuating haemodynamic responses to laryngoscopy and tracheal intubation.Timepoint: AT 1,2,3,5,10 AND 15 MINUTES	—

Secondary

Measure	Time frame
1.To measure the change in mean arterial pressure and heart rate after laryngoscopy and tracheal intubation at defined time interval for 15 minutes. 2.To observe postoperavtive adverse effects like dizziness, somnolence, nausea and vomiting for next 24 hrs after surgery. Timepoint: OVER A PERIOD OF 15 MINUTES	—

Countries

India

Contacts

Public ContactMATHANGI BRUNDA

SRI VENKATESWARA INSTITUTE OF MEDICAL SCIENCES

aloksvims@gmail.com9493547653

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026