Comparision of monitored anaesthesia care(a type of sedation ) with spinal anaesthesia in day care varicose vein surgery and its effect on stress gene expression

COMPARISON OF MONITORED ANAESTHESIA CARE WITH SPINAL ANAESTHESIA IN DAY CARE VARICOSE VEIN SURGERY AND ITS EFFECT ON STRESS GENE EXPRESSION

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/02/031086

Enrollment

Registered

2021-02-08

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I830- Varicose veins of lower extremities with ulcer

Interventions

Intervention1: COMPARISION OF MONITORED ANAESTHESIA CARE WITH SPINAL ANAESTHESIA AND EFFECT OF BOTH TECHNIQUES ON MODULATION OF STRESS GPX3 GENE: COMPARISION OF MONITORED ANAESHESIA CARE USING DEXMEDE

Eligibility

Inclusion criteria

Inclusion criteria: PATIENTS GIVING WRITTEN INFORMED CONSENT AGED BETWEEN 18 YEARS TO 60 YEARS ASA GRADE I AND II

Exclusion criteria

Exclusion criteria: REFUSAL OF PATIENTS PATIENTS UNDERGONE GENERAL ANAESTHESIA WIHIN 7 DAYS , HAD TAKEN ALPHA-2 AGONIST WITHIN 14 DAYS PATIENTS WHO HAD EXPERIENCED ACUTE STABLE ANGINA OR MYOCARDIAL INFARCTION WITHIN PREVIOUS 6 WEEKS PATIENTS WITH LIVER CIRRHOSIS , THROMBOCYTOPENIA,COAGULOPATHIES,THIRD DEGREE HEART BLOCK AND CONTRAINDICATION FOR NEURAXIAL BLOCK SEVERE BRADYCARDIA,AND SYSTOLIC BLOOD PRESSURE LESSTHAN 90 MM HG PREGNANT FEMALE CURRENT PSYCHIATRIC DISORER KNOWN DRUG ALLERGY TO THE STUDY DRUGS ASA GRADE III AND IV

Design outcomes

Primary

Measure	Time frame
PRIMARY OUTCOME PARAMETER IS GENE EXPRESSIONTimepoint: PRIMARY OUTCOME WILL BE ASESSED ON THE DAY OF SURGERY	—

Secondary

Measure	Time frame
TO COMPARE THE INTRAOPERATIVE HEMODYNAMIC CHANGES IN BETWEEN MONITORED ANAESTHESIA CARE WITH DEXMEDETOMIDINE AND SPINAL ANAESTHESIA WITH ROPIVCAINE TO ASSESS THE POST OPERATIVE RECOVERY STATUS OF PATIENTS IN TERMS OF EARLY AMBULATIONTimepoint: AT BASELINE AND DURING THE PERIOD OF SURGERY;TO EVALUATE THE SEDATIVE AND ANAGLGESIC EFFECT OF DEXMEDETOMIDINE DURING MONITORED ANAESTHESIA CARE IN VARICOSE VEIN SURGERY TO STUDY THE LOCAL ANAESTHETIC EFFECT OF ROPIVACAINE IN SPINAL ANAESTHESIA IN VARICOSE VEIN SURGERY TO INVESTIGATE THE MODULATION OF STRESS GPX3 GENES WITH EXPOSURE TO TWO ANAESTHESIA TECHNIQUES Timepoint: AT BASELINE AND AFTER SURGERY	—

Measure

Time frame

TO COMPARE THE INTRAOPERATIVE HEMODYNAMIC CHANGES IN BETWEEN MONITORED ANAESTHESIA CARE WITH DEXMEDETOMIDINE AND SPINAL ANAESTHESIA WITH ROPIVCAINE TO ASSESS THE POST OPERATIVE RECOVERY STATUS OF PATIENTS IN TERMS OF EARLY AMBULATIONTimepoint: AT BASELINE AND DURING THE PERIOD OF SURGERY;TO EVALUATE THE SEDATIVE AND ANAGLGESIC EFFECT OF DEXMEDETOMIDINE DURING MONITORED ANAESTHESIA CARE IN VARICOSE VEIN SURGERY TO STUDY THE LOCAL ANAESTHETIC EFFECT OF ROPIVACAINE IN SPINAL ANAESTHESIA IN VARICOSE VEIN SURGERY TO INVESTIGATE THE MODULATION OF STRESS GPX3 GENES WITH EXPOSURE TO TWO ANAESTHESIA TECHNIQUES Timepoint: AT BASELINE AND AFTER SURGERY

—

Countries

India

Contacts

Public ContactDR RAJNI GUPTA

KING GEORGES MEDICAL UNIVERSITY

rgkgmu@gmail.com9839288980

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026