Health Condition 1: C50- Malignant neoplasm of breast
Conditions
Interventions
Intervention1: Administration of Melatonin: 6mg of Melatonin to group M orally 120 minutes before induction of anaesthesia
Control Intervention1: Administration of Gabapentin: 600mg of Gabapentin to g
Sponsors
Kanika Bansal
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients giving written informed consent 2. Womwen of age group 20-60 years 3. ASA Grade I,II,III
Exclusion criteria
Exclusion criteria: Negative consent ASA IV Pregnancy History of confusion/ dementia/ communication difficulty Chronic use of narcotics/ barbiturates/ psychotropic medication Allergy to any of the drug to be used
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Post operative pain intensity by VAS (Visual Analog Scale),Total analgesic requirement in first 24 hours, time of requirement of first rescue analgesia 2. Anxiety (verbal anxiety score) Timepoint: 1. Post operative pain intensity at 0, 1, 2, 6, 12, 24 hours after arrival in the recovery room, total analgesic requirement in first 24 hours, time of requirement of first rescue analgesia 2. Anxiety level is assessed at time of drug administration, just before induction of anaesthesia preoperatively and postoperatively at 0, 1, 2, 6, 12, 24 hours after arrival in the recovery room | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Sedation level using Ramsay Sedation Scale 2. Effect on sleep using sleep quality index 3. Post operative cognitive dysfunction using MMSE scaleTimepoint: 1. Sedation level is assessed at 0,1,2,6,12,24 hours postoperatively 2.Sleep quality is assessed on day 1,2,3 postoperatively 3. Post operative cognitive dysfunction is assessed on day1, day3, 1week, 3week postoperatively | — |
Countries
India
Contacts
Public ContactDr Jyotsna Agrawal
King George Medical University, Lucknow
Outcome results
None listed