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ROLE OF VITAMIN C AND THIAMINE IN SEPSIS INDUCED REFRACTORY HYPOTENSION

EVALUATION OF THE EFFECTS OF VITAMIN-C AND THIAMINE ON REFRACTORY HYPOTENSION IN PATIENTS WITH SEPSIS:A RANDOMIZED CONTROL STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/02/031043
Enrollment
75
Registered
2021-02-05
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R652- Severe sepsis

Interventions

Intervention1: Ascorbic acid: 25 mg/kg 6 hourly for 72 hours intravenous route Intervention2: Thiamine: 2 mg/kg 6 hourly for 72 hours intravenous route Control Intervention1: Vitamin C: 25 mg/kg 8 hou

Sponsors

DR RAM MANOHAR LOHIA INSTITUTE OF MEDICAL SCIENCES
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1-PATIENTS WITH SEPTIC SHOCK WITH REFRACTORY HYPOTENSION 2-CONSENT FOR PARTICIPATION IN THE STUDY FROM LEGITIMATE GUARDIAN

Exclusion criteria

Exclusion criteria: 1-PREGNANCY 2-G6PD DEFICIENCY 3-PATIENTS ON ANTIPSYCHOTIC MEDICATIONS 4-PRE-EXISTING PULMONARY HYPERTENSION 5-H/O RENAL STONE,CHRONIC ALCOHOLISM,IRON OVERLOAD

Design outcomes

Primary

MeasureTime frame
TO EVALUATE THE EFFECTS OF VITAMIN-C AND THIAMINE ON MORTALITY BENEFIT IN PATIENTS WITH SEPSIS HAVING REFRACTORY HYPOTENSIONTimepoint: After 7 days from the time of start of vitamin-c or thiamine administration time—

Secondary

MeasureTime frame
TO STUDY THE EFFECTS OF VITAMIN-C AND THIAMINE ON HEMODYNAMIC PARAMETERS IN PATIENTS WITH SEPSIS HAVING REFRACTORY HYPOTENSIONTimepoint: 6 HOURLY MEASUREMENT OF HEMODDYNAMIC PARAMETERS FOR OVER 72 HOURS PERIOD FROM THE TIME OF ADMINISTRATION OF VITAMIN-C OR THIAMINE—

Countries

India

Contacts

Public ContactDR NANDHINI N

DR RAM MANOHAR LOHIA INSTITUTE OF MEDICAL SCIENCES

drdm58@gmail.com05226692063

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026