A comparitive study between two drugs esmolol and dexmedetomidine for inducing regulated hypotension in functional endoscopic sinus surgery

Controlled hypotension in functional endoscopic sinus surgery: A randomized controlled trial comparing esmolol and dexmedetomidine

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/02/031034

Enrollment

Registered

2021-02-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Controlled hypotension in functional endoscopic sinus surgery:A randomized controlled trial comparing esmolol and dexmedetomidine: Randomly selected patients having ASA physical status

Eligibility

Inclusion criteria

Inclusion criteria: Randomly selected patients admitted in ENT ward with nasal pathology belonging to American Society of Anaesthesiologists (ASA)status I and II, aged between 18 and 55 years of either sex and willing to give written consent will be included in the study

Exclusion criteria

Exclusion criteria: Patient refusal Any known hypersensitivity or contraindication to esmolol, dexmedetomidine,nitroglycerine,fentanyl Uncontrolled hypertension Cardiovascular diseases including conduction disturbances Renal or hepatic dysfunction Coagulation disorders Patients on medications affecting coagulation system Pregnant or lactating mothers Paediatric patients Patients on calcium channel blockers Patients with history of significant neurological, psychiatric or neuromuscular disorders

Design outcomes

Primary

Measure	Time frame
Intraoperative blood lossTimepoint: After induction of anaesthesia, every 15mins for first hour and every 30 mins thereafter.	—

Secondary

Measure	Time frame
Duration of surgery, duration of controlled hypotension (min), number of patients treated with fentanyl (%), min fentanyl dose per patient (mcg), number of patients treated with nitroglycerine,min nitroglycerine used per patient (mg), hemodynamics intraoperatively,oxygen saturation (spo2) during controlled hypotension and any other adverse effects during study periodTimepoint: Hemodynamic monitoring will be recorded preoperatively, after induction of anaesthesia, after intubation,every 15 mins for the first hour and every 30 mins thereafter and after extubation	—

Measure

Time frame

Duration of surgery, duration of controlled hypotension (min), number of patients treated with fentanyl (%), min fentanyl dose per patient (mcg), number of patients treated with nitroglycerine,min nitroglycerine used per patient (mg), hemodynamics intraoperatively,oxygen saturation (spo2) during controlled hypotension and any other adverse effects during study periodTimepoint: Hemodynamic monitoring will be recorded preoperatively, after induction of anaesthesia, after intubation,every 15 mins for the first hour and every 30 mins thereafter and after extubation

—

Countries

India

Contacts

Public ContactAnkita Kar

I.P.G.M.E.R., S.S.K.M. Hospital

drankitadas29@gmail.com7044935419

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026