Evaluation of effect of preoperative duloxetine (antidepressant) on reducing postoperative morphine requirement after open radical cholecystectomy

EVALUATION OF EFFECT OF PREOPERATIVE DULOXETINE ON REDUCING POSTOPERATIVE MORPHINE REQUIREMENT AFTER OPEN RADICAL CHOLECYSTECTOMY : A RANDOMISED CONTROL STUDY

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/02/031033

Enrollment

Registered

2021-02-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C23- Malignant neoplasm of gallbladder

Interventions

Intervention1: DULOXETINE: Duloxetine group would receive 60 mg duloxetine orally 2 hours prior to surgery with a sip of water and postoperatively total morphine requirement would be measured at the e

Eligibility

Inclusion criteria

Inclusion criteria: ASA I TO lll AGED BETWEEN 20 YEARS TO 70 YEARS UNDERGOING OPEN RADICAL CHOLECYSTECTOMY UNDER GENERAL ANAESTHESIA FOR CARCINOMA GALL BLADDER

Exclusion criteria

Exclusion criteria: PATIENTS NOT GIVING CONSENT PREGNANT AND NURSING MOTHERS PATIENTS WHO HAVE DULOXETINE OR MORPHINE ALLERGY PREEXISTING PAIN SYNDROME DRUG OR ALCOHOL ABUSE

Design outcomes

Primary

Measure	Time frame
TO STUDY THE EFFICACY OF PREOPERATIVE DULOXETINE ON TOTAL MORPHINE REQUIREMENT AT 24 HOURS AFTER OPEN RADICAL CHOLECYSTECTOMYTimepoint: TO STUDY THE EFFICACY OF PREOPERATIVE DULOXETINE ON TOTAL MORPHINE REQUIREMENT AT 24 HOURS AFTER OPEN RADICAL CHOLECYSTECTOMY	—

Secondary

Measure	Time frame
TO ASSESS THE TIME TO FIRST RESCUE ANALGESIC REQUIREMENT TO MEASURE VAS SCORE AT 30 MINUTES 1 HOUR 6 HOUR 12 HOUR AND 24 HOUR TO ASSESS THE PATIENT SATISFACTION POSTOPERATIVELY TO STUDY THE SIDE EFFECTS OF DULOXETINETimepoint: 1 YEAR	—

Countries

India

Contacts

Public ContactDR APARNA SHUKLA

KING GEORGE MEDICAL UNIVERSITY

draparnashukla@yahoo.com9918038878

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026