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The timing of administration of a steroid, dexamethasone, on the postoperative relief from pain in women undergoing uterus removal surgery.

The effect of pre-emptive versus post-surgery single dose intravenous dexamethasone on post-operative analgesia and recovery outcomes in women undergoing open total abdominal hysterectomy under spinal anaesthesia: A randomized double blind study.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/02/031024
Enrollment
66
Registered
2021-02-04
Start date
Unknown
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Post-surgical dexamethasone: Single dose 8 mg intravenous dexamethasone given at the end of surgery(before starting of closure) Control Intervention1: Pre-emptive dexamethasone: Single

Sponsors

Dr Premangshu Ghoshal
Lead Sponsor
Dr Satyajeet Misra
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing open total abdominal hysterectomy under spinal anaesthesia

Exclusion criteria

Exclusion criteria: Refusal to give consent, Known history of Corticosteroid hypersensitivity, Diabetes Mellitus patients, Increased Preoperative TLC Count, Patients already receiving corticosteroid or immunosuppresive drugs preoperatively, Previous history of gastric ulcer, Receiving other analgesics, Patients for whom general anesthesia will be required because of unexpectedly prolonged surgery for any reason or because of any complication

Design outcomes

Primary

MeasureTime frame
VASTimepoint: 6 hours—

Secondary

MeasureTime frame
24 hour incidence of PONVTimepoint: Upto 24 hours post-operatively;Cumulative 24 hours Opioid UseTimepoint: Upto 24 hours post-operatively;Difference in VASTimepoint: 24 hours;Duration of post-operative hospital stay in daysTimepoint: Until hospital discharge;Duration of stay in recovery unitTimepoint: Upto 6 hours post-operatively;Incidence of any wound infectionTimepoint: Until hospital discharge;Time in minutes to request for first analgesicTimepoint: Upto 8 hours post-operatively;Time to passage of faecesTimepoint: Until hospital discharge;Time to regression of motor blockade by Modified Bromage Scale and sensory blockade to 2 dermatomal levelsTimepoint: Upto 4 hours post-operatively—

Countries

India

Contacts

Public ContactDr Satyajeet Misra

All India Institute of Medical Sciences, Bhubaneswar

misrasatyajeet@gmail.com9438884048

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026