Health Condition 1: K027- Dental root caries
Conditions
Interventions
Intervention1: Self Assembling peptide matrix gel: Self-assembling peptide matrix (SAPM) gel will be applied to the tooth surfaces before and after the completion of radiotherapy. The SAPM application
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: a) Patients of either gender between of age group 18-60 years b) Diagnosis of oral cavity and oropharyngeal squamous cell carcinoma(stage I- IV B) c) Planned radiation dose of � 50 Gy d) Availability of at least eight teeth after oral health clearance e) Patients with adequate motor function to perform routine oral hygiene practices
Exclusion criteria
Exclusion criteria: a) Patients with advanced periodontal disease, diabetes and severely debilitated patients with advanced tumors b) Patients with need of surgical intervention and reconstruction therapy for management of oral cavity and oropharyngeal carcinoma c) Patients not willing to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| development of post radiation cariesTimepoint: at 6 and 12 months post radiation therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| reduced salivary flow rateTimepoint: 3,6 and 12 months | — |
Countries
India
Contacts
Public ContactVijay Kumar
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed