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Comparison of two regimens of total intravenous anaesthesia for time to recovery from anaesthesia.

Randomised Controlled Trial to compare time to post operative recovery after opioid free total intravenous anaesthesia using propofol with ketamine or dexmedetomidine in patients undergoing elective surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/02/030967
Enrollment
60
Registered
2021-02-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M84- Disorder of continuity of bone Health Condition 2: K87- Disorders of gallbladder, biliarytract and pancreas in diseases classified elsewhere Health Condition 3: K26- Duodenal ulcer Health Condition 4: K25- Gastric ulcer Health Condition 5: K21- Gastro-esophageal reflux disease Health Condition 6: C67- Malignant neoplasm of bladder Health Condition 7: C18- Malignant neoplasm of colon Health Condition 8: C15- Malignant neoplasm of esophagus Health Condition 9: C23- Maligna

Interventions

Intervention1: ADBIULFAUIPQP: FNRREUIQFNQI
QEIO
EQGBGR Intervention2: propofol and dexmedetomidine: infusion dexmedetomidine @1mcg/kg over 10 min folowed by infusion dexmedetomidine 0.5mcg/kg/hr. infusion propofol 200mcg/kg/min to maintain a BIS of

Sponsors

LADY HARDINGE MEDICAL COLLEGE
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA I and ASA II 2.Undergoing elective surgery of duration 1-4 hours

Exclusion criteria

Exclusion criteria: 1.Any known allergy to drugs used in the study. 2.Known psychiatric illness. 3.Narrow angle glaucoma. 4.Addiction to drugs and alcohol. 5.Chronic opioid therapy

Design outcomes

Secondary

MeasureTime frame
1.haemodynamic complications (bradycardia, tachycardia, hypotension, hypertension) 2.Mean Bi-spectral index 3.Total propofol requirement (mcg/kg/min; Mean dose±SD) 4.Total 24hrs analgesic requirement 5.post-operative nausea and vomiting 6.irrelevant talk, hallucination 7.explicit recallTimepoint: intraoperative haemodynamics every 5 minutes and BIS every 10 min At the end of surgery and 24 hours postoperative

Primary

MeasureTime frame
Time taken to achieve Modified Aldrete Score of �9 (Mean±SD) using propofol with ketamine or dexmedetomidineTimepoint: postoperative every minute till Modified Adrette Score is more than or equal to 9

Countries

India

Contacts

Public ContactNishant Kumar

LHMC

kumarnishant@yahoo.co.uk9811934659

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026