effect of two drug (clonidine vs midazolam-fantanyl) in anesthesia for varicose vein surgery and relation with COMT gene

Comparison of clonidine vs midazolam-fentanyl in monitored anaesthesia care for varicose vein surgery and its correlation with pain modulating COMT gene

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/02/030955

Enrollment

Registered

2021-02-03

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I838- Varicose veins of lower extremities with other complications

Interventions

Intervention1: clonidine midazolam-fantanyl: clonidine 1mcg/kg bolus by clonidine i.v. infusion at 0.1mcg/kg/hr midazolam0.06mg/kg + fantanyl 1mcg/kg over 10 min followed by infusion i.v. .2ml/kg/hr

Eligibility

Inclusion criteria

Inclusion criteria: AGE BETWEEN 18YEARS TO 60 YEARS ASA GRADE 1 & 2 DIAGNOSED CASE OF VARICOSE VEIN PATIENT GIVING WRITTEN INFORMED CONSENT WILL BE TAKEN

Exclusion criteria

Exclusion criteria: PATIENT REFUSAL PATIENT UNDERGONE GENERAL ANAESTHESIA WITH IN 7 DAYS, HAD TAKEN ALPHA-2 AGONIST WITH IN 14 DAYS HEART BLOCK PSYCHIATRIC DISORDER ASA 3 & 4

Design outcomes

Primary

Measure	Time frame
To evaluate the sedative and analgesic effect of clonidine vs midazolam-fentanyl in Monitored Anesthesia Care (MAC) during varicose vein surgery.Timepoint: 1 year	—

Secondary

Measure	Time frame
Effects of the COMT gene on modulating pain and its association. To assess the intra operative hemodynamic stability. To assess the post-operative safety and efficacy . Timepoint: 1 year	—

Countries

India

Contacts

Public ContactDr Rajni Gupta

king georges medical university , lucknow

rgkgmu@gmail.com9839288980

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026