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Factors Determining Central Sensitization (pain hypersensitivity due to CNS reasons) in Osteoarthritis Knee

Factors Determining Central Sensitization in Osteoarthritis Knee

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/01/030834
Enrollment
345
Registered
2021-01-29
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M170- Bilateral primary osteoarthritis of knee

Interventions

None listed

Sponsors

Vardhman Mahavir Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Knee osteoarthritis diagnosed on the basis of American College of Rheumatology criteria with pain duration of at least 3 months duration

Exclusion criteria

Exclusion criteria: 1. Known case of cervical or lumbar radiculopathy, systemic inflammatory conditions (like Rheumatoid arthritis, Ankylosing spondylitis), diabetes mellitus with neuropathy or peripheral vascular disease 2. Previous surgery or disease of peripheral or central nervous system, sensory loss due to chemotherapy or radiotherapy 3. Any intervention on knee like injection or total knee replacement 4. Associated hip osteoarthritis 5. History of taking antidepressant or anticonvulsant or strong opioids 6. Secondary osteoarthritis in knee

Design outcomes

Primary

MeasureTime frame
Numerical Pain Rating Scale (NRS) Knee Pain Mapping KL Grading of OA Knee Widespread Pain Index (WPI) Depression Anxiety and Stress Scale (DASS21) Central Sensitisation Inventory (CSI)Timepoint: 3months

Secondary

MeasureTime frame
Relationship between NRS, Knee pain mapping, KL Grading , Widespread Pain Index, DASS 21 , CSI and Central SensitisationTimepoint: 45 minutes

Countries

India

Contacts

Public ContactBhawna

Vardhman Mahavir Medical College, Safdurjung Hospital

shweta_10775@yahoo.co.in01126707173

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026