FindTrial
Sign In

Estimation and comparison of serum levels of Mannose Binding Lectin, SIRT-1 and C-reactive Protein in smokers and non-smokers with stage III periodontitis before and after non-surgical periodontal therapy.

Comparative evaluation of effect of Non-surgical Periodontal Therapy on serum levels of Mannose binding lectin, SIRT-1 and C-reactive Protein in Smokers and Non-smokers with Stage III periodontitis: A Case Control Study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/01/030833
Enrollment
105
Registered
2021-01-29
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis Health Condition 2: V00-Y99- External causes of morbidity

Interventions

Control Intervention1: blood serum levels of Mannose Binding Lectin, SIRT-1 and C-reactive Protein: Mannose Binding Lectin and SIRT-1 will be evaluated using Enzyme Linked Immunosorbent Assay kit and

Sponsors

Dr Aishwarya Purohit
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Periodontally healthy patients 2.Non-Smoker patients 3.Current Smoker patients

Exclusion criteria

Exclusion criteria: 1. Patients who have undergone any periodontal therapy in the past 6 months. 2. Patients with any systemic disease and self-reported psychiatric disorders. 3. Patients with symptoms of acute illness. 4. Patients who are on immunosuppressive therapy. 5. Systemic anti-inflammatory treatment within the previous 3 months or regular use of specific drugs known to affect periodontal tissues.

Design outcomes

Primary

MeasureTime frame
Decreased serum levels Mannose-binding lectin and C-reactive protein and increase in serum levels of SIRT-1. after non-surgical periodontal therapy in smokers and non-smokers with stage III periodontitisTimepoint: baseline and 6 weeks after non-surical periodontal therapy—

Secondary

MeasureTime frame
Improved gingival index and plaque index score , reduced bleeding on probing and gain in clinical attachment level after non-surgical periodontal therapy in smokers and non-smokers with stage III periodontitis.Timepoint: baseline and 6 weeks after non-surical periodontal therapy—

Countries

India

Contacts

Public ContactDr Abhay Kolte

VSPM Dental College and Research Centre, Nagpur

drrajashrikolte@gmail.com9011071468

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026