FindTrial
Sign In

Efficacy of mechanical power in predicting weaning of patients from invasive ventilation, who are on mechanical ventilator for acute worsening of chronic obstructive pulmonary disease

Efficacy of Mechanical Power in Predicting Weaning Outcome of Patients receiving Invasive Mechanical Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/01/030817
Enrollment
63
Registered
2021-01-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J441- Chronic obstructive pulmonary disease with (acute) exacerbation

Interventions

Intervention1: Nil: Nil

Sponsors

None
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Admision to ICU for acute exacerbation of chronic obstructive pulmonary disease 2.Acute respiratory failure (PaCO2 > 50 mm Hg, PaO2 3.Tracheal intubation with controlled mechanical ventilation

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. History of neuromuscular disease 3. Chest wall deformities 4. Intracranial hypertension 5. Septic shock. 6. Refusal to consent. 7. Need of mechanical ventilation for less than 24hr hours 8. Respiratory failure requiring invasive mechanical ventilation for condition other than acute exacerbation of chronic obstructive pulmonary disease 9. Existing tracheostomy 10. Required long term ventilation within past 3 months. 11. Associated Interstitial lung disease 12. Lobar pneumonia 13. Presence of pulmonary edema

Design outcomes

Primary

MeasureTime frame
To evaluate the efficacy of mechanical power (on invasive mechanical ventilation) in predicting difficult weaning of patients with acute exacerbation of chronic obstructive pulmonary disease.Timepoint: At admission after 15 minutes of intubation and initiation of invasive mechanical ventilation (Day 1) At 24 hours(Day2) Day2-Day28—

Secondary

MeasureTime frame
Other outcome parameters (morbidities in ICU, nutritional parameters, prolonged weaning, unsuccessful weaning, Post-extubation NIV need, Post-extubation failure, ventilator free days, ICU length of stay, ICU free days, in-hospital length of stay, readmission to ICU, ICU mortality, and 28-day mortality)Timepoint: Day1-Day28;Baseline parameters (Demographics, SOFA score, APACHE II score, Arterial blood gas, diagnosis and co-morbidities).Timepoint: At admission(Day1) ;To analyse correlation between positive end expiratory pressure and mechanical power in patients receiving invasive mechanical ventilation for acute exacerbation of chronic obstructive pulmonary disease.Timepoint: At admission after 15,20,25,30,35,40,45,50,55,60,65 minutes of intubation and initiation of invasive mechanical ventilation (Day1) At 24 hours(Day2) ;To evaluate the efficacy of mechanical power (on invasive mechanical ventilation) in predicting simple weaning of patients with acute exacerbation of chronic obstructive pulmonary disease.Timepoint: At admission after 15 minutes of intubation and initiation of invasive mechanical ventilation (Day 1) At 24 hours(Day2) Day2-Day28—

Countries

India

Contacts

Public ContactDr Gaurav Jain

All India Institute of Medical Sciences,Rishikesh

gauravhld@gmail.com8808631209

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026