Health Condition 1: F32- Major depressive disorder, singleepisode
Conditions
Interventions
Intervention1: role of tibolone in postmenopausal depression: EFFECTIVENESS OF TIBOLONE IN POST MENOPAUSAL DEPRESSION in dose of 2.5 mg/day oral given daily for 12 weeks
Intervention2: Study will comp
Sponsors
Department of psychiatry
Eligibility
Inclusion criteria
Inclusion criteria: • Females who have currently achieved natural menopause • Physiologic menopause with amenorrhea for at least 1 year • Able to give informed consent • First-onset or relapse depression during menopause • Patients of depression diagnosed acc to DSM 5 criteria
Exclusion criteria
Exclusion criteria: 1. Patients with any history of thyroid dysfunction, active or past history of a venous thromboembolic event, breast pathology, undiagnosed vaginal bleeding or abnormal Pap smear results . 2. Patients with any significant unstable medical illness such as epilepsy and diabetes or known active cardiac, renal or liver disease; or the presence of illness causing immobilisation. 3.Patients with psychotic symptoms or past history of severe mental illness. 4. Use of any form of estrogen, progestin or androgen as hormonal therapy, or antiandrogen including Tibolone or use of phytoestrogen supplements as powder or tablet 5. Smoking cigarettes or other nicotine products 6. Illicit drug use 7. More than 3 standard drinks per day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To study effectiveness of tibolone in post menopausal depression and anxiety by HAM D, HAM ATimepoint: baseline, 2 weeks , 4 weeks , 8 weeks , 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 2. To assess change in quality of life of post menopausal women with tibolone. By WHO QOL scale 4. To assess sexual functioning among Postmenopausal women and change in sexual functioning with tibolone. By ASEX, FSFI Timepoint: baseline, 2 weeks, 4 weeks, 8 weeks and 12 weeks | — |
Countries
India
Contacts
Public ContactNamita Sharma
Government Medical college patiala
Outcome results
None listed