Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium
Conditions
Interventions
Intervention1: Test group: INTRAVENOUS NOREPINEPHRINE INFUSION (50ML/H rate) at dose of 0.05MCG/KG/MIN) initiated at time of intrathecal injection and continued till delivery of baby.
Control Interve
Sponsors
University College of Medical Sciences and GTB HOSPITAL
Eligibility
Inclusion criteria
Inclusion criteria: Otherwise healthy pregnant patients scheduled for elective cesarean section under combined-spinal-epidural block, with an uncomplicated singleton pregnancy of 37 weeks or greater gestation will be included
Exclusion criteria
Exclusion criteria: body mass index >30 kg/m2, who refuse consent, with preeclampsia, history of diabetes mellitus, cardiovascular or cerebrovascular diseases, fetal abnormalities, or any contraindication to combined spinal epidural block
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| minimum effective dose (ED50) of intrathecal hyperbaric bupivacaine (0.5%) along with 10 µg fentanyl during elective cesarean section, with and without an intravenous prophylactic norepinephrine infusion titrated to maintain blood pressureTimepoint: To determine the ED90 of bupivacaine, sensory and motor block characteristics will be evaluated EVERY 3 mins till 3 identical readings or 15 minutes (whichever is later). | — |
Secondary
| Measure | Time frame |
|---|---|
| Intrathecal block characteristics (sensory and motor) between both groups, among patients with adequate block: Timepoint: The sensory and motor block will be evaluated every 3 mins till till 3 identical readings or 15 minutes (whichever is later). Followed by every 15 mins till end of surgery; and then every 30 mins till sensory block recedes by 2 segments in postoperative room. | — |
Countries
India
Contacts
Public ContactDR MONIKA MATHUR
University College of Medical Sciences and GTB Hospital
Outcome results
None listed