FindTrial
Sign In

A clinical study assessing blood flow changes in brain during intra arterial therapy in patients treated for aneurysmal sub arachnoid hemorrhage

Cerebral hemodynamic changes during therapeutic intra-arterial infusion in patients treated for aneurismal subarachnoid hemorrhage â?? An observational study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/01/030732
Enrollment
50
Registered
2021-01-25
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G00-G99- Diseases of the nervous system

Interventions

None listed

Sponsors

nil
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age more than 18 years. Aneurysmal SAH originating from vessel in anterior cerebral circulation

Exclusion criteria

Exclusion criteria: Patient refusal Hemodynamically unstable patient requiring more than one inotropic infusions. Aneurysmal SAH originating from vessel in posterior cerebral circulation. Before scheduled intraarterial vasodilator therapy, patients having undergone decompressive craniectomy for management of cerebral swelling.

Design outcomes

Primary

MeasureTime frame
To study changes in Cerebral Blood Flow Volume (CBF Vol) and Cerebral Flow velocities (FV) before and after intra-arterial vasodilator therapy in patients with anterior circulation aneurysmal sub arachnoid hemorrhage.Timepoint: Baseline, 5 min, 10 min, 15 min, 20 min, 25 min, 30 min, 2 hrs, 4 hrs and 24 hrs—

Secondary

MeasureTime frame
To assess cerebral auto regulatory status with TCD using transient hyperemic response ratio (THRR) before and after intra-arterial vasodilator therapy.Timepoint: Baseline, 5 min, 10 min, 15 min, 20 min, 25 min, 30 min, 2 hrs, 4 hrs and 24 hrs;To compare changes in CBF Vol and FV of affected intracranial vessel to extracranial internal carotid artery (ICA) before and after intra-arterial vasodilator therapy.Timepoint: Baseline, 5 min, 10 min, 15 min, 20 min, 25 min, 30 min, 2 hrs, 4 hrs and 24 hrs;To correlate ultrasonographic (USG) measurements of cerebral vessels to DSA based measurement.Timepoint: Baseline, 30 min—

Countries

India

Contacts

Public ContactDr Anagh Chakravorty

NIMHANS, Bangalore

dhritiman.ch@gmail.com8197781240

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026