between palonosetron and aprepitant which one is better in preventing nausea and vomiting in females undergoing laparoscopic surgery

Efficacy of Aprepitant versus Palonosetron for prevention of nausea and vomiting among females undergoing laparoscopic surgery

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/01/030613

Enrollment

Registered

2021-01-20

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R112- Nausea with vomiting, unspecified

Interventions

Intervention1: palonosetron: 5HT3 receptor antagonist,given by intravenous injection,OD,dose-0.075mg Control Intervention1: Aprepitant: NK1 receptor antagonist,oral route,dose 40mg,OD

Eligibility

Inclusion criteria

Inclusion criteria: Females aged 20 to 65 yrs of ASA Class1 and 2 scheduled to undergo laparascopic surgery

Exclusion criteria

Exclusion criteria: 1.pregnancy 2.weight 100 3.smokers 4.history of PONV 5.steroid use 6.abnormal liver function test 7.abnormal renal function test

Design outcomes

Primary

Measure	Time frame
Comparative incidence of postoperative nausea and vomiting in patients undergoing laparoscopic procedures who have been administered palonosetron or aprepitantTimepoint: Comparative incidence of postoperative nausea and vomiting in patients undergoing laparoscopic procedures who have been administered palonosetron or aprepitant at 2hr,6hr,12hr,24hr,48hr after extubation	—

Secondary

Measure	Time frame
need for use of an additional anti emetic in post operative periodTimepoint: immediately after extubation 2 hr after extubation 6 hr after extubation 12 hr after extubation 24 hr after extubation 48 hr after extubation;need for use of an analgesic in post operative periodTimepoint: immediately after extubation 2 hr after extubation 6 hr after extubation 12 hr after extubation 24 hr after extubation 48 hr after extubation	—

Measure

Time frame

need for use of an additional anti emetic in post operative periodTimepoint: immediately after extubation 2 hr after extubation 6 hr after extubation 12 hr after extubation 24 hr after extubation 48 hr after extubation;need for use of an analgesic in post operative periodTimepoint: immediately after extubation 2 hr after extubation 6 hr after extubation 12 hr after extubation 24 hr after extubation 48 hr after extubation

—

Countries

India

Contacts

Public ContactDr Subhashree Mishra

VIMSAR

drbimalpanda@gmail.com9437175425

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026