Health Condition 1: K859- Acute pancreatitis, unspecified
Conditions
Interventions
Intervention1: Patients in the twice daily arm will receive, in addition, enoxaparin sodium 1 mg/kg twice daily (the recommended therapeutic dosage in deep vein thrombosis and pulmonary embolism), fro
Sponsors
ILBS
Eligibility
Inclusion criteria
Inclusion criteria: All adult cases of severe acute pancreatitis , who do not match exclusion criteria ,admitted to ILBS during study period will be included in the study .
Exclusion criteria
Exclusion criteria: Patients with: -chronic pancreatitis. -hypersensitivity to LMWH -Pregnant or breast feeding ladies - pediatric age group - prior coagulopathy. - CLD with acute pancreatitis. - Stroke/ CVA(Cerebro-Vascular Accident) - Established SP axis thrombus - Presentation beyond 10 days from onset of pancreatitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective comparison of clinical degree of severity and organ failure scores in the two arms as evaluated by SOFA, APACHE II scores at day 7 and day 14 of therapyTimepoint: Baseline, Day 7 and Day 14 of therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.In hospital mortality. 2.Duration of ICU Stay 3.Duration of Hospital stay 4. Thrombotic complications- SPM-axis thrombosis 5.Haemorrhagic complications- GI haemorrhage, Intra-pancreatic haemorrhage, Post intervention haemorrhage. 6.Need for IR, MIS, Surgery for local complications. 7.Coagulopathy: Changes in ROTEM 8.CRP level at day 3, 7, 14 Timepoint: At admission, day 3, day 7, day 14 and throughout hospital stay depending upon parameter as mentioned in secondary outcome parameteres. | — |
Countries
India
Contacts
Public ContactDr Shridhar Vasantrao Sasturkar
ILBS , Vasant Kunj
Outcome results
None listed