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A study to compare the effect of early versus late initiation of hemodialysis in patients with acute kidney injury due to snake bite with respect to overall survival and progression to chronic kidney disease.

A comparative study of early versus late initiation of renal replacement therapy in patients with acute kidney injury due to snake envenomation and its impact on the short-term and long-term outcome of the kidney function

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/01/030545
Enrollment
60
Registered
2021-01-18
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N17- Acute kidney failure

Interventions

Intervention1: Renal replacement therapy (Hemodialysis): Early renal replacement therapy (RRT) initiation strategy - Initiation of hemodialysis within 12 hours of diagnosis of KDIGO Stage 2 AKI. Cont

Sponsors

Nil Ratan Sircar Medical College and Hopsital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. A definite history of snake bite. 2. Clinical picture consistent with that of a hematotoxic snake bite. 3. Age 18-65 years. 4. Stage 2 acute kidney injury according to KDIGO classification. 5. Informed consent provided by the patient or relatives.

Exclusion criteria

Exclusion criteria: 1. Patients with Stage 3 acute kidney injury at presentation. 2. Patients with evidence of pre-existing renal disease. 3. Need for emergency hemodialysis even before randomization. 4. Patient received hemodialysis in outside hospital.

Design outcomes

Primary

MeasureTime frame
Primary objectives are: a) Survival at the end of 30 days. b) To see whether there is progression to chronic kidney disease.Timepoint: 30 days, 90 days.—

Secondary

MeasureTime frame
Secondary objectives are: a) Requirement of renal replacement therapy at 90 days. b) Survival at 90 days.Timepoint: 90 days—

Countries

India

Contacts

Public ContactAbhishek Mukherji

Nil Ratan Sircar Medical College and Hopsital

drpinaki71@yahoo.com9836471071

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026