Health Condition 1: G400- Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset
Conditions
Interventions
Control Intervention1: Dexmedetomidine-isoflurane: Effects of dexmedetomidine-isoflurane combination on electrocorticography
Isoflurane will be given at a dial concentration of 0.5 to 1% to maintain a
Sponsors
GB PANT INSTITUTE OF POST GRADUATE MEDICAL EDUCATION AND RESEARCH
Eligibility
Inclusion criteria
Inclusion criteria: Patients with medically intractable epilepsy requiring surgery requiring surgery with electrocorticography guidance under general anaesthesia
Exclusion criteria
Exclusion criteria: Patients with bradysrryhthmias,hypotension, uncontrolled hypertension, pregnancy, hepatic and renal impairment, cardiac disease, morbid obesity, known allergy to anaesthetic drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in electrocorticographyTimepoint: 1. ECoG score obtained when dexmedetomidine is combined with isoflurane- recorded after the bolus dose of dexmedetomidine 2. EDP â?? EP; where EP is ECoG score obtained when propofol is administered alone and EDP is ECoG score obtained when dexmedetomidine is combined with propofol 3. (EDI â?? EI) Vs (EDP â?? EP) the comparison of the difference of ECoG score obtained with the use of dexmedetomidine between the two regimes | — |
Secondary
| Measure | Time frame |
|---|---|
| Haemodynamic alterations, recovery pattern, intraoperative awareness,Timepoint: Haemodynamics- HR and MAP-Baseline (after placement of subdural grid electrodes), After dexmed infusion @ 1mcg/kg for 5 minutes, After completion of dexmed bolus dose, every fifteen minutes till completion of surgery Recovery pattern- emergence time and extubation time Intraop awareness- Brice questionnaire 24 hrs post surgery | — |
Countries
India
Contacts
Public ContactDr Pragati Ganjoo
GB Pant hospital
Outcome results
None listed