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A COMPARATIVE STUDY OF EFFICACY OF ORAL TRANEXAMIC ACID AND ITS COMBINATION WITH Nd-YAG LASER IN MELASMA.

A RANDOMISED , OPEN LEVEL COMPARATIVE STUDY OF CLINICAL EVALUATION BETWEEN ORAL TRANEXAMIC ACID VERSUS Q SWITCHED Nd-YAG LASER AND ORAL TRANEXAMIC ACID IN MELASMA.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/01/030539
Enrollment
50
Registered
2021-01-18
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L814- Other melanin hyperpigmentation

Interventions

Intervention1: oral tranexamic acid with nd YAG laser: In Group B patients along with Tab Tranexamic acid 250mg twice daily for 3 months, Nd-YAG Laser will be used simultaneously. Control Intervention

Sponsors

Dr Abdul Sahid Khan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All the patients with melasma of age 18years to 50years attending SKIN & VD OPD in between the study period

Exclusion criteria

Exclusion criteria: 1.Patients with history of coagulopathies, cardiac diseases and severe systemic disorders. 2.Use of oral anticoagulant drugs or any other photosensitizing drugs such as NSAID, tetracycline, spironolactone, phenytoin, carbamazepine in last 1 month. 3.Known allergy to Tranexamic acid. 4.Use of other depigmenting oral or topical agents in the past 1 month. 5.Females with a history of pregnancy/lactation in last 12 months. 6.Use of oral contraceptive pills/hormonal replacement therapy in the past 12 months. 7.Patients with unusually high expectations.

Design outcomes

Primary

MeasureTime frame
The combination of Oral Tranexamic acid and Qs Nd-YAG laser is expected to be better with minimum 60% decrease in MASI score where as only Oral Tranexamic acid is expected to have a reduction in MASI by 40-45%. Timepoint: the patients will be evaluated after 6months of the beginning of treatment to see for the change in masi scores.—

Secondary

MeasureTime frame
To see the efficacy of Oral Tranexamic acid in Melasma. To see the efficacy of Oral Tranexamic acid and Q Switched Nd-YAG laser in Melasma. To see if Oral Tranexamic acid decreases the side effects of Q Switched Nd-YAG lasers in comparison to other studies. To compare the efficacy of oral Tranexamic acid with Q switched Nd YAG laser against Oral Tranexamic acid alone in cases of Melasma. Timepoint: patients will be evaluated at monthly interval , and before and after each laser session to see for improvement and side effects.—

Countries

India

Contacts

Public ContactDR ABDUL SAHID KHAN

SCB Medical college and hospital

titoon@rediffmail.com7381231102

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026