Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: ENTERAL SILDENAFIL: Tablet Sildenafil will be administered orally or through nasogastric tube, thrice a day, in moderate and severe Covid-19 patients
Intervention2: Tablet Sildenafil: T
Sponsors
Sardar Vallabh Bhai Patel Covid Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Established case of Covid-19 (RTPCR +ve) 2. Moderate Covid-19 patients (SpO2 90 â?? 94% on room air, RR 24 â?? 30/min) with visible radiographic features of pneumonia 3. Severe Covid-19 patients (SpO2 30/min) with visible radiographic features of pneumonia
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating women 2. Patients on Nitrate medications in any form 3. Patients with any malignant tumor 4. Patients with heart ailments including Myocardial Infarction (in 5. Patients with mental illness or stroke ( 6. Advanced liver or kidney ailment 7. Patients with known history of severe systemic hypertension especially if uncontrolled 8. Patients with systemic hypotension because of any reason. 9. Patients allergic to Sildenafil 10. Patients already on mechanical ventilation 11. Patients with inability to take drug orally or inability to place Ryleâ??s tube.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To observe Sildenafil effect on Covid-19 progression including clinical findings, oxygenation and radiological findingsTimepoint: Three weeks or hospital discharge or death whichever is first | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) To observe Sildenafil effect on inflammatory markers (CRP, D-Dimer, IL-6, Procalcitonin) and need for ventilation 2) To monitor any adverse events related to Sildenafil use Timepoint: Three weeks or hospital discharge or death | — |
Countries
India
Contacts
Public ContactSaajan Joshi
Sardar Vallabh Bhai Patel Covid Hospital, Ulan Bater Road, Delhi Cantt, New Delhi
Outcome results
None listed