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EFFECT OF DRUGS ON POSTOPERATIVE INFLAMMATORY MARKERS AFTER SINGLE VALVE REPLACEMENT SURGERY

EFFECTS OF INTRAVENOUS DEXMEDETOMIDINE ON POSTOPERATIVE SERUM PROCALCITONIN LEVELS FOLLOWING CARDIO PULMONARY BYPASS IN SINGLE VALVE REPLACEMENT SURGERY:A PROSPECTIVE,RANDOMISED,CONTROLLED,DOUBLE-BLINDED TRIAL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/01/030408
Enrollment
60
Registered
2021-01-12
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I342- Nonrheumatic mitral (valve) stenosis

Interventions

Intervention1: EFFECTS OF IV DEXMEDETOMIDINE ON POSTOPERATIVE SERUM PROCALCITONIN: ALL PATIENTS WILL BE GIVEN GENERAL ANAESTHESIA AND WILL BE INDUCED WITH MIDAZOLAM 2 MG, DEXMEDETOMIDINE 1MCG/KG OVER

Sponsors

Dr RAJESHWAR ZALA
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ADULTS PATIENTS AGED 18 TO 70 YEARS, AMERICAN SOCIETY OF ANAESTHESIOLOGISTS (ASA) GRADE I,II,III.,BMI <28KG/M2, PATIENTS WHO COMPLIED WITH SURGICAL INDICATION FOR SINGLE VALVE REPLACEMENT SURGERY, EJECTION FRACTION - 60% OR MORE.

Exclusion criteria

Exclusion criteria: H/O FEVER IN LAST TWO WEEKS, TLC >11000 (PRE-EXISTING INFECTION), NSAIDS AND PREOPERATIVE STEROIDS BEFORE 2 WEEKS OF SURGERY, ALLERGY TO STUDY DRUGS, NEUROLOGICAL OR PSYCHIATRIC DISEASE, HEPATIC DISEASE, SEVERE RENAL INSUFFICIENCY, RESPIRATORY DISEASE

Design outcomes

Primary

MeasureTime frame
TO COMPARE THE EFFECTS OF IV DEXMEDETOMIDINE ON SERUM PROCALCITONIN LEVELS VERSUS CONTROL GROUP IN SINGLE VALVE REPLACEMENT SURGERY DONE ON CARDIOPULMONARY BYPASSTimepoint: FROM INDUCTION TO 72 HRS POST OPERATIVELY—

Secondary

MeasureTime frame
HEMODYNAMIC VARIABLES, BODY TEMPERATURE, COMPLETE BLOOD COUNT, ADVERSE EFFECTS LIKE NAUSEA, VOMITING, DROWSINESS, HYPOTENSION, BRADYCARDIA, RESPIRATORY DEPRESSION, PRURITUSTimepoint: FROM INDUCTION TO 72 HRS POST OPERATIVELY—

Countries

India

Contacts

Public ContactDr KALPESHKUMAR MISTRY

GEETANJALI MEDICAL COLLEGE AND HOSPITAL

drkalpesh001@gmail.com09784586454

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026