Health Condition 1: N179- Acute kidney failure, unspecified
Conditions
Interventions
Intervention1: Drug : aminophylline: Babies fulfilling the inclusion criteria will receive 1 dose of injection aminophylline within 1 hour of life depending upon the random code number.
Control Interv
Sponsors
Mohit Bansal
Swami Dayanand hospital
Eligibility
Inclusion criteria
Inclusion criteria: Neonates �37 weeks Appropriate for Gestational Age(AGA), who have birth asphyxia manifested by any of the following : 1. H/o fetal distress(late decelerations, decreased heart rate variability, or bradycardia). 2. Apgar score of � 3 at 1 minute or � 5 at 5 minutes. 3. Base deficit equal to or greater than 15mEq/l in cord blood or admission ABG/VBG samples. 4. Requirement of immediate positive pressure ventilation with bag and mask or intubation with endotracheal tube for >1 minute after delivery.
Exclusion criteria
Exclusion criteria: 1. Antenatally diagnosed congenital abnormalities of the kidney and/or urinary tract. 2. CVS abnormalities not related to perinatal asphyxia. 3. Prenatal or neonatal exposure to medications that might have modified renal hemodynamics. 4. Any gross congenital malformation or chromosomal abnormality.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse events following aminophylline administration like tachycardia, hyperglycemia, and vomiting.Timepoint: till 24 hours post aminophylline injection.;Outcome of neonates in both groups in terms of I. Duration of hospital stay II. Mortality Timepoint: birth to discharge from hospital.;Severity of AKI as per neonatal Kidney Disease Improving Global Outcome (KDIGO) criteria.Timepoint: birth to 5 days of life | — |
Primary
| Measure | Time frame |
|---|---|
| Renal function as per measurement of : 1. Serum creatinine 2. urine output 3. creatinine clearanceTimepoint: At 24 hours, 72 hours, and 120 hours of life in both groups. | — |
Countries
India
Contacts
Public ContactMohit Bansal
MBBS MD PEDIATRICS
Outcome results
None listed