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Role of sperm in pregnancy outcome

Understanding the influence of sperm epigenetic variations on early embryo development

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/01/030369
Enrollment
298
Registered
2021-01-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N469- Male infertility, unspecified

Interventions

None listed

Sponsors

ICMR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Fertile donor ejaculates and Normozoospermia, Asthanozoospermia, Oligozoospermia, Oligoasthanozoospermia infertile patients

Exclusion criteria

Exclusion criteria: Teratozoospermia, Globozoospermia, Necrozoospermia, Azoospermia, Cryptozoospermia infertile patients

Design outcomes

Primary

MeasureTime frame
This present study is expected to unravel the differential epigenetic signature of spermatozoa between infertile male patients and fertile controls, and in between normal and abnormal ejaculates.Timepoint: 3 years—

Secondary

MeasureTime frame
to understand the contribution of altered epigenetic signature of spermatozoa on pre-implantation embryo developmental kinetics, and preimplantation embryo metabolism.Timepoint: 3 years—

Countries

India

Contacts

Public ContactSatish Kumar Adiga

Manipal Academy of Higher Education

satish.adiga@manipal.edu9945671115

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026