Health Condition 1: H163- Interstitial and deep keratitis
Conditions
Interventions
Intervention1: voriconazole: 50µg/0.1 ml dose, given by intrastromal route as an adjunct to topical therapy.
Repeated maximum thrice, if there is no improvement or worsening of the keratitis
Control
Sponsors
Rajendra Prasad Centre for Ophthalmic Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1)Moderate to severe non-perforated ulcer. 2)Evidence of fungus on KOH or culture 3)Admitted in the ward 4)Consent to receive medications as per protocol
Exclusion criteria
Exclusion criteria: 1) Mild cases of fungal keratitis 2)Impending perforation 3)Evidence of bacteria on Gram stain / acanthamoeba 4)Evidence of herpetic keratitis:history or exam 5)Age less than 18 years 6)Bilateral ulcers 7)Previous surgery in affected eye within 1 year 8)Pregnancy or breast-feeding (by history) 9) Acuity worse than 6/60 (20/200) in fellow eye. 10) h/o known allergy to drugs being used
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in best corrected visual acuityTimepoint: At baseline, 3 days, 7 days, 14 days, 21 days, 28 days, 3 months and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to resolution of epithelial defect size of residual infiltrate/ scarTimepoint: At baseline, 3 days, 7 days, 14 days, 21 days, 28 days, 3 months and 6 months | — |
Countries
India
Contacts
Public ContactGunjan Saluja
474, RAJENDRA PRASAD CENTRE FOR OPHTHALMIC SCIENCES AND RESEARCH
Outcome results
None listed