Health Condition 1: null- Severe Mastalgia (true breast pain) not responding to three months of treatment with first line drugs (danazol, centchroman, tamoxifen)
Conditions
Interventions
Intervention1: Injection Leupride and Tablet Cenchroman: Depot Injection leupride 3.75 mg will be given subcutaneously for three doses at 0,1,2 months with a daily dose of Tablet centchroman 30 mg onc
Sponsors
All India Institute of Medical Sciences Delhi
Eligibility
Inclusion criteria
Inclusion criteria: Women giving consent with recalcitrant mastalgia, normal menstrual cycles, non pregnant, no personal history of breast or ovarian cancer.
Exclusion criteria
Exclusion criteria: Cancer breast/ovary, Pregnancy, breast feeding or lady desiring pregnancy in next 6 months, Lady with PCOD or cervical hyperplasia, Lady not giving consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relief of pain in to a VAS score of 3 or less at 4 weeks of starting treatmentTimepoint: Relief of pain in to a VAS score of 3 or less at 4 weeks of starting treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the safety and patient compliance of complete estrogen blockade using LHRH analogue and centchroman with LHRH analogue and tamoxifen when given as a therapy for recalcitrant mastalgia.Timepoint: 03 months | — |
Countries
India
Contacts
Public ContactSuhani
All India Institute of Medical Sciences
Outcome results
None listed