Health Condition 1: - Health Condition 2: - Health Condition 3: K703- Alcoholic cirrhosis of liver Health Condition 4: K754- Autoimmune hepatitis Health Condition 5: K721- Chronic hepatic failure Health Condition 6: C220- Liver cell carcinoma Health Condition 7: O- Medical and Surgical Health Condition 8: K746- Other and unspecified cirrhosis ofliver Health Condition 9: K743- Primary biliary cirrhosis Health Condition 10: K744- Secondary biliary cirrhosis Health Condition 11: K717- Toxic liver
Conditions
Interventions
Intervention1: Carica Papaya Leaf Extract: 1100mg of Carica Papaya Leaf Extract given 3 times a day starting atleast 3 days and upto 2 weeks prior to planned date of liver transplant, and continued in
Sponsors
Institute of Liver and Biliary Sciences
Eligibility
Inclusion criteria
Inclusion criteria: All consenting adults who are planned to undergo living donor liver transplant with platelet counts less than or equal to 75000/uL preoperatively
Exclusion criteria
Exclusion criteria: 1. patients who do not consent 2. ALF & ACLF 3. Pediatric Transplant recipients 4. History of allergy to papaya 5. Preoperative platelet counts >75000/uL 6. Recent history of DVT 7. Presence of portal vein thrombosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-operative Day 7 platelet countsTimepoint: Baseline, 1 day prior to surgery, Post operative Day 1,2,3,4,5,6 and 7 | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6 levelsTimepoint: on Post-operative Day 3 and post-operative day 7;Incidence of early allograft dysfunctionTimepoint: upto post-operative day 14;Incidence of prolonged post-operative drainageTimepoint: post-operative day 14;Intra-operative blood lossTimepoint: Day of liver transplant;Intra-operative transfusion requirementsTimepoint: Day of liver transplant;Pre-operative platelet countsTimepoint: 1 day prior to liver transplant;S. Thrombopoeitin levelsTimepoint: On Post-operative day 3 and post-operative day 7 | — |
Countries
India
Contacts
Public ContactDr Anubhav
Institute of Liver and Biliary Sciences
Outcome results
None listed