Health Condition 1: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx
Conditions
Interventions
None listed
Sponsors
Dr Naveena Kumar AN
Eligibility
Inclusion criteria
Inclusion criteria: 1. Locally advanced primary oral SCC who underwent curative surgery (pT3 and above, pN1 and above). 2. Age more than 18 years. 3. Patients with normal organ and marrow function as below a. Hemoglobin > 8 g/L b. Total WBC >= 3000/mcL or Absolute neutrophil count (ANC) > 1.5 x 109/L c. Platelets >= 100000/mcL d. Total bilirubin e. AST(SGOT)/ALT(SGPT) f. Adequate renal function with Creatinine clearance > 30 ml/min
Exclusion criteria
Exclusion criteria: 1. Early SCC oral cavity (pT1, pT2, pN0) 2. Patient with locally advanced SCC oral cavity, who have not received standard surgery and/or adjuvant treatment. 3. Recurrent/second primary oral malignancy 4. Age more than 80 years 5. Pregnant women 6. Patient not fit for Metronomic chemotherapy 7. Patients with QTc prolongation defined as QTc interval greater than 0.5 seconds (celecoxib associated sudden cardiac death) 8. Patient not giving informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| disease free survival, demographical, epidemiological and clinical data of locally advanced oral cancer.Timepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Gene expression and mRNA profile, preclinical study dataTimepoint: 3 years | — |
Countries
India
Contacts
Public ContactDr Mahadev Rao
Manipal College of Pharmaceutical Sciences Manipal Academy of Higher Education
Outcome results
None listed