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Increased renal function in an adult intensive care setting -prevalence, risk factors and impact on clinical outcomes

Augmented Renal Clearance in an Adult Intensive Care Setting â?? Prevalence, Risk Factors and Impact on Clinical Outcomes

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/01/030243
Enrollment
278
Registered
2021-01-05
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A00-B99- Certain infectious and parasitic diseases Health Condition 2: D50-D89- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism Health Condition 3: I00-I99- Diseases of the circulatory system Health Condition 4: K00-K95- Diseases of the digestive system Health Condition 5: H60-H95- Diseases of the ear and mastoid process Health Condition 6: G00-G99- Diseases of the nervous system Health Condition 7: J00-J99- Diseases of the

Interventions

None listed

Sponsors

Kandaswamy N
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age > 18 years 2.Receiving antibiotics 3.Within 24 hours of ICU admission 4.Expected ICU stay > 24hours 5.Has an indwelling urinary catheter or has the indication to insert one

Exclusion criteria

Exclusion criteria: 1.AKI on admission (as defined by KDIGO guidelines if preadmission creatinine is available and as per MDRD study calculation if preadmission creatinine is not available) 2.Non-index ICU admission 3.Chronic kidney disease as defined eGFR 4.Trauma/surgery involving kidneys 5.Renal replacement therapy (RRT) 6.Patients with crush injury

Design outcomes

Primary

MeasureTime frame
To identify the prevalence of augmented renal clearance in a mixed cohort of medical, surgical and trauma patients receiving antibiotic therapy in an adult intensive care setting of a tertiary care hospital.Timepoint: within 24hrs of admission to ICU to the time of discharge from ICU—

Secondary

MeasureTime frame
a)To describe the correlation between eGFR(estimated glomerular filtration rate) measured by MDRD4(modification of diet in renal disease study equation with 4 variables) formula, Cockcroft-gault equation, CKD-EPI(Chronic kidney disease epidemiology collaboration) formula with measured 24hr urinary creatinine clearance. b)To identify the risk factors associated with ARC c)Effect of ARC on clinical outcomes 1. ICU length of stay (LOS) 2. ICU survivalTimepoint: within 24hrs of admission to ICU to the time of discharge from ICU—

Countries

India

Contacts

Public ContactKandaswamy N

All India Institute of Medical Sciences

vimirewari@gmail.com9999247802

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026