Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: Methylpredinesolone: Drug-Methylprednisolone
Dose-1 to 2 mg/kg body weight
Route- IV
Frequency- daily infusion over 24 hours
Duration-10 days
Control Intervention1: Dexamethasone
: Dr
Sponsors
Maulana Azad Medical College and associated Lok Nayak Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1.Confirmed COVID-19 infection with pulmonary involvement 2.Admitted to ICU within 14 days of onset of symptoms 3.Receiving Invasive or non -invasive positive pressure ventilation or respiratory support through HFNC
Exclusion criteria
Exclusion criteria: Septicemia 2. Active malignancy or patient on immunosuppressive therapy within last 3 months 2.Uncontrolled hyperglycaemia 3.Clinically important gastrointestinal bleed 4.Pregnancy 5.History of hypersensitivity to steroid preparations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28 day Mortality of patientsTimepoint: 28 days | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse effects of steroidsTimepoint: any time during hospitalization;Clinical status of patients accroding to WHO 7 category COVID outcome ordinal scaleTimepoint: 7 and 14 days after randomization;PaO2/FiO2Timepoint: 5,7 and 14 days after randomization;Sequential organ failure assessment (SOFA) scoreTimepoint: 5,7 and 14 days after randomization | — |
Countries
India
Contacts
Public ContactDr Sukhyanti Kerai
Maulana Azad Medical College
Outcome results
None listed