IMPACT OF VAMANA KARMA(THERAPEUTICALLY INDUCED EMESIS) AND TRIPHALA AND GUDUCHI CHURNA WITH MADHU ON THE MODULATION OF GUT MICROBIOTA.

A COMPARATIVE STUDY TO INVESTIGATE THE EFFECT OF VAMANA KARMA AND TRIPHALA AND GUDUCHI CHURNA WITH MADHU ON GUT MICROBIOTA AND METABOLITE PATTERNS IN PRAMEHA W.S.R TO TYPE 2 DIABETES MELLITUS AND HEALTHY INDIVIDUALS.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/12/030107

Enrollment

Registered

2020-12-29

Start date

Unknown

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E119- Type 2 diabetes mellitus without complications Health Condition 2: E119- Type 2 diabetes mellitus without complications

Interventions

Intervention1: Vamana Followed by Triphala and Guduchi Churna with Madhu in Prameha Individuals W.S.R to Type 2 Diabetes Mellitus: 1. Vamana Karma(therapeutically induced emesis for internal bio-clean

Eligibility

Inclusion criteria

Inclusion criteria: For Prameha(Type 2 Diabetes Mellitus) Individuals- 1. BMI>= 20 2. Kaphaj/Kapha-pittaj Vikriti predominant individuals 3. Diagnosed cases of Prameha/Madhumeha/T2DM with either of the following- a) Fasting plasma glucose values of >= 7.0 mmol/L (126 mg/dl) b) 2-h post-load plasma glucose >= 11.1 mmol/L (200 mg/dl) c) HbA1c >= 6.5% (48 mmol/mol) d) Random blood glucose >= 11.1 mmol/L (200 mg/dl) 4. Chronicity: Up to 10 years For Healthy Individuals 1. BMI>= 20 2. Kaphaj/Kapha-pittaj Prakriti predominant Individuals as per Proforma for Prakriti Assessment by CSIR Ayurgenomics Unit- TRISUTRA CSIR-IGIB, NEW DELHI 3. Healthy individuals as per Proforma for Health Assessment by self-reporting of CSIR Ayurgenomics Unit- TRISUTRA CSIR-IGIB, NEW DELHI

Exclusion criteria

Exclusion criteria: Patients unfit for Snehana(Internal Oleation), Svedana(Sudation), Vamana(therapeutically induced emesis for internal bio-cleansing). For Prameha(Type 2 Diabetes Mellitus)- 1. Patients with T2 DM exceeding the following plasma glucose limits- a) Fasting plasma glucose values of >= 300mg/dL b) 2-h post-load plasma glucose>=400mg/dL c) Random blood glucose>= 400mg/dL 2. Chronicity: More than 10 years. 3. Known cases of Severe systemic diseases like- Cardiac disease, pulmonary tuberculosis, severe lung disease, uncontrolled diabetes and pregnant women.

Design outcomes

Primary

Measure	Time frame
Reduction in Sign and Symptoms of Prameha(T2DM)patients(By questionnaire Scoring Pattern). To see the impact of Classical Vamana karma followed by administration of Triphala and Guduchi Churna with Madhu on gut microbiota diversity and metabolite patterns in Prameha (w.s.r Type 2 Diabetes Mellitus).Timepoint: 56-68 days	—

Secondary

Measure	Time frame
Whole microbiome and metabolome Analysis of both Prameha and healthy individuals to see the impact of classical Vamana karma on Gut Microbiome and metabolomes. To evaluate change in Plasma Glucose level in the patients of Prameha (w.s.r T2 DM). To see improvement in the quality of life.Timepoint: 56-68days	—

Countries

India

Contacts

Public ContactNISHANT MALHOTRA

ALL INDIA INSTITUTE OF AYURVEDA

santoshbhatted@rediffmail.com8130711860

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026