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IRole of preoperative vitaminD, magnesium, and phosphate on the development of postoperative hypocalcemia following total thyroidectomy.

Influence of Preoperative Vitamin-D, Serum Magnesium and Serum Phosphate levels on the development of transient and permanent hypocalcemia and hypoparathyroidism following total thyroidectomy with or without central compartment clearance in patients with thyroid cancer (HypoCal Study). - HypoCal Study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/12/030092
Enrollment
353
Registered
2020-12-29
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C73-C75- Malignant neoplasms of thyroid and other endocrine glands

Interventions

Intervention1: NIL: NIL

Sponsors

TATA MEMORIAL HOSPITAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with differentiated thyroid cancer-all variants, Medullary thyroid carcinoma (Familial/Sporadic)who would undergo total or completion thyroidectomy with or without central compartment clearance and lateral neck dissection at TMH. 2. Age above 18 years. 3. Consenting patients willing to follow up at TMH.

Exclusion criteria

Exclusion criteria: 1. Patients with Renal or Liver disease. 2. Patients with MTC as part of MEN 2a & 2b. 3. Patients suffering from Malabsorption, Musculoskeletal diseases & Hyperparathyroidism. 4. Patients on medications known to affect calcium metabolism, such as bisphosphonates, calcitonin, gallium nitrate, plicaycin, glucocorticoids.

Design outcomes

Primary

MeasureTime frame
To assess the influence of (pre-operative) vitamin D levels on the development of post-operative hypocalcaemia. Timepoint: To assess the influence of (pre-operative) vitamin D levels on the development of post-operative hypocalcaemia(Signs and symptoms of hypocalcemia and hypoparathyroidism will be noted in the post- operative period and on follow-up).—

Secondary

MeasureTime frame
1. Influence and interaction of Sr. Magnesium and Phosphate on post-operative hypocalcaemia and hypoparathyroidism incidence. 2.To assess Quality of life using EORTC-THY-34 Questionnaire. Timepoint: 1.Total Serum calcium, albumin, 25-OHD, Serum magnesium, Sr. Phosphate would be measured preoperatively on the day before surgery,Post-operatively on POD-1,POD-5 or before discharge whichever earlier;Repeat measurements will be done at 1-2 month, 5-7 months and after 12 months. 2.Quality of life will be assessed using EORTC-THY-34 Questionnaire at the time of follw-up.—

Countries

India

Contacts

Public ContactDr SHIVAKUMAR THIAGARAJAN

Tata Memorial Centre

drshiva78in@gmail.com9846572399

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026