Health Condition 1: - Health Condition 2: C184- Malignant neoplasm of transverse colon
Conditions
Interventions
Intervention1: Epidural Morphine- Bupivacaine intermittent Bolus: Epidural analgesia will be provided by Morphine 0.05 mg/kg diluted to 10 ml with Bupivacaine 0.1% solution [3 mg Morphine (1 ml) + 2ml
Sponsors
Tata Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients who will undergo elective GI oncosurgery 2. American Society of Anaesthesiology (ASA-PS) score of 1 to 3
Exclusion criteria
Exclusion criteria: 1.Hepatobiliary and pancreatic surgery 2.Thoracic surgery 3.Patients with life threatening arrhythmias 4.Patients with left ventricular ejection fraction (LVEF) 5.Acute myocardial infarction (within 30 days) 6.Acute pulmonary oedema (within 7 days) 7.Chronic obstructive pulmonary disease with a forced expiratory volume (FEV1) in the first second of expiration of less than 50% 8.Emergency surgery 9.Coagulopathy (platelet x2 control, INR >1.5) 10.Significant liver dysfunction (liver enzymes >x3 times normal) 11.Significant renal dysfunction (creatinine >x2 times normal) 12.Psychiatric disorders 13.Sepsis before surgery. 14.Patients who have known hypersensitivity to any of the drugs used during the procedure 15.Patients who are not willing to sign the informed consent form 16.History of any significant condition which the investigator feels would interfere with study evaluations and study participation 17.Patients who are on transdermal opioids or long acting analgesics 18.Patients who have previously participated in this study and to undergo a second surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intravenous fentanyl requirement as rescue analgesiaTimepoint: In 1st 24 hrs Post surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of hospital stayTimepoint: Length of hospital stay from the day of surgery to fitness to discharge will be noted.;Postoperative fluid administrationTimepoint: Hourly fluid intake and urine output will be measured during intraoperative and postoperative period;Postoperative pain scoreTimepoint: Pain score of the patient on rest and during spirometry in visual analog scale will be asked after shifting the patient to PACU and 1,6, 12, 24 hrs in 1st postoperative day and after that two times every day till POD 5;Requirement of vasopressorsTimepoint: If there is hemodynamic compromise [hypotension (SBP 90mm of Hg), urine output 0.5ml/kg/hr] intravenous fluid bolus with 5ml/kg will be infused. If hypotension persists even after fluid bolus, vasopressors will be given as per institutional protocol. Maximum Noradrenalin dose required to maintain normal haemodynamics will be noted during intraoperative period and every postoperative day.;Time to enteric resumptionTimepoint: Postoperative day when patient tolerated 500 ml enteric liquid will be documented. | — |
Countries
India
Contacts
Public ContactRudranil Nandi
Tata Medical Center, Kolkata
Outcome results
None listed