Skip to content

To compare the effect of prophylactic infusion of intravenous phenylephrine, nor epinephrine and mephentermine for maintenance of blood pressure in patients undergoing elective caesarean section under spinal anesthesia

TO COMPARE THE EFFECT OF INFUSION DOSES OF INTRAVENOUS PHENYLEPHRINE, NOREPINEPHRINE AND MEPHENTERMINE FOR MAINTENANCE OF BLOOD PRESSURE DURING SPINAL ANAESTHESIA IN CAESAREAN SECTION AND THEIR EFFECTS ON NEONATE.

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/12/030039
Enrollment
240
Registered
2020-12-24
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: phenylephrine: Patients will be randomized into three groups ââ? â?? Group P- will receive infusion phenylephrine 50mcg/ml @ 0.1mcg/kg/min ââ? â?? Group N- will receive infusion n

Sponsors

kalinga institute of medical sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 21-40 years 2. ASA II 3. Singleton term pregnancy 4. Elective caesarean section 5. Parturient with no co-morbidity

Exclusion criteria

Exclusion criteria: 1. Pre-existing pregnancy-induced hypertension 2. Cardiovascular disease 3. Hepato-renal disease 4. Use of cardiac medication or medication for blood pressure control 5. Gestational diabetes mellitus requiring insulin 6. Suspicion of abnormal placentation 7. Allergy to study drugs 8. Intraoperative use of uterotonic other than oxytocin 9. Known fetal abnormality 10. Contraindication to subarachnoid block

Design outcomes

Primary

MeasureTime frame
� To compare the effect of prophylactic infusion of intravenous phenylephrine, nor epinephrine and mephentermine for maintenance of blood pressure in patients undergoing elective caesarean section under spinal anesthesia .Timepoint: Blood pressure and heart rate recorded every 2 minutes until delivery.

Secondary

MeasureTime frame
Incidence of bradycardia,hypertension,hypotension. -Total doses of rescue drug required. -Neonatal APGAR scores at 1 and 5 minutes. -To find the incidence of post operative nausea and vomiting. Timepoint: Blood pressure and heart rate recorded every 2 minutes until delivery.

Countries

India

Contacts

Public ContactDR BRIG GANESH CHANDRA SATAPATHY

KIMS

ganesh.satapathy@kims.ac.in8283872939

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026