Health Condition 1: G20- Parkinsons disease
Conditions
Interventions
Intervention1: Nicotine patch: 14mg/24hr nicotine patch applied for about 6-8 hours
Control Intervention1: placebo skin patch: placebo patch
Sponsors
National Brain Research Centre
Eligibility
Inclusion criteria
Inclusion criteria: - non-smoker ( >10 years) - able to provide informed consent
Exclusion criteria
Exclusion criteria: The subjects may not be eligible to participate if he/she - - Has any neurological disorder (except PD in the patient group) - Has a current depressive episode, schizophrenia or bipolar disorder (self-declared and screened with GHQ-12 (Goldberg et al., 1978; Qin et al., 2018)) - Has had any head injury with loss of consciousness - Has had any seizures in the past - Has cognitive impairment (Mini Mental Status Examination (MMSE) test score - Abuses drugs/alcohol - Is pregnant or nursing Subjects will not be eligible for MRI scanning if they - - Have non-MRI compatible metal in the body such as a cardiac pacemaker, brain stimulator, surgical metal, cochlear implants, artificial heart valves or dental implants. - Are unable to lie flat on the back for the duration of the scan. - Have uncontrollable head movements. - Are claustrophobic. Subjects will not be eligible to undergo TMS if they â?? - Have metal implants in the body such as brain stimulator, surgical metal, cochlear implants, cardiac pacemaker, intracardiac lines, implanted pumps or stimulators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Motor cortical inhibition, Motor cortical plasticityTimepoint: baseline, 4 hours after patch, 1 hour after levodopa medication | — |
Secondary
| Measure | Time frame |
|---|---|
| cortical connectivity cortical reactivityTimepoint: baseline, 4 hours after patch, 1 hour after levodopa | — |
Countries
India
Contacts
Public ContactNivethida T
National Brain Research Centre (NBRC)
Outcome results
None listed