Health Condition 1: A419- Sepsis, unspecified organism Health Condition 2: E116- Type 2 diabetes mellitus with other specified complications
Conditions
Interventions
Intervention1: NIL: NIL
Control Intervention1: NIL: NIL
Sponsors
Manipal Academy of Higher Education
Eligibility
Inclusion criteria
Inclusion criteria: Healthy Non-diabetic control – Age 40 – 65 years, Fasting glucose less than 100mg/dl Non-diabetic subjects with Sepsis – Non Diabetic and bacterial sepsis Type 2 Diabetes – HbA1c grater than 8.0% Type 2 Diabetes with sepsis - HbA1c greater than 8.0% and bacterial sepsis
Exclusion criteria
Exclusion criteria: Iatrogenic or endogenous Cushing’s syndrome, Usage of glucocorticoids, Non-bacterial sepsis, Immunosuppression and autoimmune diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The present proposal addresses underlying mechanisms due to cross talk between granulopoiesis and metabolism in T2D conditions. Evolving knowledge of host-pathogen interaction in T2D might provide innovative, preventive and therapeutic approaches for infectious disease and inflammatory disorders. Our study will identify novel cellular and molecular mechanisms regulating neutrophil (dys)function in T2D.Timepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Findings possess translational potential and will facilitate to develop diagnostic markers.Timepoint: 3 years | — |
Countries
India
Contacts
Public ContactMr Kailash G
Manipal School of Life Sciences
Outcome results
None listed