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Investigation of Semaphorin 4D Levels in gingival crevicular fluid of healthy gums and in pyorrhea and itâ??s response to teeth cleaning treatment .

Evaluation and Comparison of Semaphorin 4D (SEMA4D) Levels in gingival crevicular fluid (GCF) of periodontally healthy, diseased subjects and itâ??s response to treatment : A Clinico-Biochemical Interventional Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/12/029934
Enrollment
50
Registered
2020-12-18
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Scaling and root planing Oral hygiene instructions: All patients with chronic periodontitist will be treated with scaling and root planing in a single sitting followed by oral hygiene

Sponsors

TPCTs Terna dental college and hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Subjects between the age group of 30 â?? 60 years. 2.Subjects who have not received periodontal therapy, within preceding six months. 3.Subjects who readily give informed consent for the study. 4.Systemically healthy patients .

Exclusion criteria

Exclusion criteria: 1.Consumption of tobacco in any form and alcoholics. 2.Pregnant and lactating females. 3. Subjects who have received anti-inflammatory, antibiotic and steroid drugs in previous three months

Design outcomes

Primary

MeasureTime frame
1.To determine the level of GCF SEMA4D in periodontally healthy patients. 2.To determine the level of GCF SEMA4D in chronic periodontitis patients. 3.To compare the levels of GCF SEMA4D in periodontally healthy and chronic periodontitis patients. 4.To correlate the effect of scaling and root planing on the level of GCF SEMA4D in patients with chronic periodontitis. Timepoint: Baseline 4 weeks after scaling and root planing

Secondary

MeasureTime frame
To evaluate improvement in plaque index ,gingival index,pocket probing depth and clinical attachment level in patients with chronic periodontitis 4 weeks after scaling and root planing .Timepoint: plaque index ,gingival index,pocket probing depth and clinical attachment level in patients with chronic periodontitis will be taken at baseline and then 4 weeks after scaling and root planing .

Countries

India

Contacts

Public ContactDr Shruti Patil

Terna dental college and hospital

rohitshah17@gmail.com9699860609

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026