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A study to compare the effectiveness of two drugs, Dexamethasone versus Methylprednisolone in the treatment of moderate Covid 19 patients

Comparing the effectiveness of Dexamethasone versus Methylprednisolone in patients with moderate Covid 19 - A Randomised controlled trial - DMC

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/12/029894
Enrollment
50
Registered
2020-12-18
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere

Interventions

Intervention1: Dexamethasone: Inj Dexamethasone 6mg/8mg IV OD X 7 Days Control Intervention1: Methylprednisolone: Inj Methylprednisolone 32mg/60mg IV OD X 6Days

Sponsors

SRM Medical College Hospital and Research Centre
Lead Sponsor
DR R Nivetha
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Hospitalized patients with moderate SARS-COV-2 infection laboratory confirmed by RT-PCR (Moderate COVID 19- SPO2 Respiratory rate 24-30/min NLR >5 CRP 50-100 mg/l Serum ferritin 600-1500 ng/ml Serum LDH 300-500 IU/l D Dimer 0.5-1.0 mic/ml IL-6 20-100 pg/ml CT chest showing 25-75% infiltrates)

Exclusion criteria

Exclusion criteria: 1.Patients with mild and severe covid pneumonia 2.Patients who are already on steroid treatment for any underlying condition 3.Patients already started on antivirals 4.Pregnant or lactating women 5.Any known contraindication to short term corticosteroid like severe immunosuppression, HIV infection or any other immunosuppressant usage Â

Design outcomes

Primary

MeasureTime frame
Mortality during hospital stayTimepoint: Day 1 - Day 7—

Secondary

MeasureTime frame
1.Time taken to wean off supplemental oxygen 2.Need for mechanical ventilationTimepoint: Day 1 of enrollment in the study to Day 7—

Countries

India

Contacts

Public ContactDR R Nivetha

SRM Medical College Hospital and Research Centre

tavidya@gmail.com9790911898

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026