Health Condition 1: K861- Other chronic pancreatitis
Conditions
Interventions
Intervention1: Pancreatic Enzyme Replacement Therapy(PERT): Patients with chronic pancreatitis with pancreatic exocrine insufficiency will receive pancreatic enzyme replacement therapy in dose (amylas
Sponsors
ICMR
Eligibility
Inclusion criteria
Inclusion criteria: patients : 1.Idiopathic chronic pancreatitis 2.With or without pancreatic exocrine insufficiency 3.Participants giving the consent Healthy Controls: 1.Relative of the patient 2.In good general health with no co morbidities(diabetes, IBD, IBS etc) 3.No pregnancy 4.No calorie restriction or other special diets 5.No known allergy 6.Not on medical treatment influencing intestinal function 7.No alcohol ( intake more than 2 pegs a day) 8.No smoking
Exclusion criteria
Exclusion criteria: 1.Concomitant medical disorder which are supposed to influence the gut microbiota like HIV, any malignancy, inflammatory bowel disease, irritable bowel syndrome, gastroenteritis, liver disease. 2.Pregnancy 3.Medical treatment influencing intestinal function 4.Subjects received antibiotics in last 3 months 5.Patients who are taking proton pump inhibitor 6.Chronic pancreatitis with another complication( symptomatic pseudocyst or GI bleed) 7.Severe pain score:16 or more
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This section would assess the status effect of following parameters in patients with chronic pancreatitis on : 1.Gut Microbiota 2.Resting energy expenditureTimepoint: 0 month and 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine the effect of 3 months pancreatic enzyme replacement therapy in patients with chronic pancreatitis with pancreatic exocrine insufficiency on: a)Levels of inflammatory cytokines b)Small intestinal bacterial overgrowth c)Body composition d)Quality of lifeTimepoint: 3 months | — |
Countries
India
Contacts
Public ContactAnoop Saraya
All India Institute of Medical Sciences
Outcome results
None listed