Health Condition 1: H401- Open-angle glaucoma Health Condition 2: E11- Type 2 diabetes mellitus Health Condition 3: H579- Unspecified disorder of eye and adnexa
Conditions
Interventions
Intervention1: Glaucoma and no diabetes: Newly diagnosed and review patients of POAG and NTG without any history of systemic illness and no clinically detectable fundus pathology other than glaucoma.
Sponsors
Aravind Eye Hospital Pondicherry
Eligibility
Inclusion criteria
Inclusion criteria: • Best corrected visual acuity of 6/12 or better, with spherical refractive error between â?? 3 diopter to + 3 diopter and a cylindrical correction within 3 diopter • Normal anterior chamber depth and open angles • No history of intraocular surgery, except cataract surgery after the 1 st post- operative month • Willing to give written informed consent The participants will be included into one of these four groups: CASES (Patients with Glaucoma) Group 1 â?? Glaucoma and no diabetes Newly diagnosed and review patients of POAG and NTG without any history of systemic illness and no clinically detectable fundus pathology other than glaucoma. Group 2 â?? Glaucoma and Diabetes Newly diagnosed and the patients presenting for review visits with POAG or NTG, with type 2 diabetes mellitus of any duration, without any other systemic illness and having no clinically visible diabetic retinopathy changes. CONTROLS (Patients without glaucoma) Group 3 â?? Controls without diabetes 1. Individuals with no history or evidence of any retinal and eye pathology. 2. Individuals with no optic disc damage clinically and no history of any systemic or neurological diseases capable of causing visual field loss or optic disc deterioration. 3. IOP 4. Open Angles Group 4 â?? Controls with Diabetes 1. New or review patients with history of type 2 diabetes mellitus of any duration having no clinically visible diabetic retinopathy changes. 2. IOP 3. Open Angles
Exclusion criteria
Exclusion criteria: Patients with any media opacity including corneal opacity, cataract greater than nuclear cataract of grade NO3 and NC3, Cortical cataract of grade C3 and Posterior subcapsular cataract of grade P3 as per Lens Opacification Classification System III 8 • Any retinal or macular pathology. • Systemic illness other than type 2 diabetes mellitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Peripapillary vessel density and capillary perfusion index 2.Area of Foveal avascular zone measured in mm 2Timepoint: At Baseline (Day 0) | — |
Secondary
| Measure | Time frame |
|---|---|
| Relation between diabetes induced retinal microvascular changes and severity of glaucomaTimepoint: At Baseline (Day 0) | — |
Countries
India
Contacts
Public ContactDr MG Pavan Kumar
Aravind Eye Hospital Pondicherry
Outcome results
None listed