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Comparison of a techniques named goal directed therapy with clinician guided regime for fluid management in COVID -19 critical care unit

Goal directed therapy guided by pulse pressure variation vs standard care for fluid management in COVID-19 critical care unit: a pilot randomised controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/12/029841
Enrollment
20
Registered
2020-12-16
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere

Interventions

Intervention1: Group II (Goal directed therapy group) : fluid therapy will be guided by dynamic parameters i.e. maintaining pulse pressure variation (PPV) less than 10%.: Group II (Goal directed thera

Sponsors

Department of OncoAnaesthesia and Palliative Medicine
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Laboratory confirmed cases of COVID-19 with severe hypoxemia, requiring invasive mechanical ventilation

Exclusion criteria

Exclusion criteria: a) age b) k/c/o CAD/ cardiac rhythm disorder c) BMI > 40 kg/m2 d) pregnant patients e) patients with coagulopathy/ bleeding disorder f) patients with motor/ neuromuscular disorder

Design outcomes

Primary

MeasureTime frame
To evaluate the effect of two strategies for fluid therapy (goal directed therapy vs standard care) on tissue perfusion as measured by serum lactate in mechanically ventilated COVID-19 patients Timepoint: 48 hours—

Secondary

MeasureTime frame
a) haemodynamic parameters b) renal functions as indicated by urine output and serum creatinine.Timepoint: at 48 hours—

Countries

India

Contacts

Public ContactDr Sushma Bhatnagar

All India Institute of Medical Sciences, Ansari Nagar, New Delhi

khushboo0411@gmail.com9888530182

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026