Health Condition 1: S00-T88- Injury, poisoning and certain other consequences of external causes
Conditions
Interventions
None listed
Sponsors
Indian Council of Medical Research
Indian Society of Neuroanesthesiology and critical care
Eligibility
Inclusion criteria
Inclusion criteria: Patient of either gender aged 18 years and above undergoing emergency cranial surgery for acute TBI with moderate or severe GCS (12-3)
Exclusion criteria
Exclusion criteria: (i) No consent (ii) Pregnant patients (iii) Contraindication to study drugs (haemodynamically unstable patient, ASA 3 or 4) (iv) Patients with maxillofacial injuries (v) Patients with factors that will affect NIRS values (like underlying scalp haematoma or pneumocephalus) (vi) Airway contamination or likelihood of pulmonary aspiration (vii) Patients already intubated in casualty
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of induction with Etomidate, Thiopentone and Propofol on rScO2Timepoint: Baseline at 0 hours Postoperative at end of 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| (i) To evaluate the effect of anesthetic induced changes in systemic hemodynamic parameters,SpO2 and to correlate it with the changes in the bilateral rScO2 (ii) To correlate the volume of hemorrhage with rScO2 changes (iii) To see effect of anesthetic induction with etomidate on serum cortisol levels (iv) To see the prognosis of the patient at end of 30 days after surgery. Timepoint: 0 TO 30 DAYS | — |
Countries
India
Contacts
Public ContactKUNAL KUMAR
NATIONAL INSTITUTE OF MENTAL HEALTH AND NEURO SCIENCES
Outcome results
None listed