Health Condition 1: K929- Disease of digestive system, unspecified
Conditions
Interventions
Intervention1: Titrated PEEP: Incrementally titrated PEEP till the lowest driving pressure is achieved
Control Intervention1: Fixed PEEP: A fixed PEEP of 5 cm H2O throughout the surgery
Sponsors
Dr Emmanuel Easterson E
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients (aged between 18 years and 75 years), of either sex undergoing Emergency Laparotomy for non-traumatic indications (of an expected duration of more than 2h) under general anaesthesia will be recruited in this study
Exclusion criteria
Exclusion criteria: Exclusion criteria 1. Patients refusal to participate in the study 2. Patients undergoing emergency laparotomy for trauma and related causes. 3. Known COPD or other chronic lung diseases 4. Preoperative diagnosis of Pneumonia 5. Known deformity of chest wall or thoracic spine 6. Pre-existing significant cardiac, renal and hepatic diseases 7. Patients with history of previous thoracic surgery. 8. BMI > 30 kg/m2, 9. Patients who are on high dose of vasopressors (defined as noradrenalin 10mcg/m or equivalent)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pulmonary complicationsTimepoint: Till postoperative day 7 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Duration of hospital stay 2. Duration of ICU stay 3. Hospital mortalityTimepoint: Till hospital discharge;1. Oxygenation status 2. Incidence of hypotension and bradycardia 3. Requirement of rescue therapy Timepoint: Intraoperative period;Oxygen free daysTimepoint: Till day 28 of randomization | — |
Countries
India
Contacts
Public ContactEmmanuel Easterson E
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed