FindTrial
Sign In

Changes in coagulation parameters with acute normovolemic hemodilution

COMPARISON OF ROTEM COAGULATION PARAMETERS WITH AND WITHOUT ACUTE NORMOVOLUMIC HAEMODILUITION IN ON PUMP CARDIAC SURGERIES â?? A RANDOMIZED CONTROLLED TRIAL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/12/029752
Enrollment
50
Registered
2020-12-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery

Interventions

Intervention1: ROTEM coagulation parameters following Acute Normovolemic Haemodilution(ANH) in On Pump Cardiac Surgeries: ROTEM coagulation parameters are evaluated in patients undergoing Acute Normov

Sponsors

AIIMS Jodhpur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: The patients scheduled to undergo on pump cardiac surgeries of American Society of Anesthesiologists (ASA) physical status class II/III, Hb >11 gm/dl and platelet count > 100000 will be enrolled in the study.

Exclusion criteria

Exclusion criteria: Patients who are not willing Emergency cardiac surgery Pre-operative subcutaneous LMWH Patients on DAPT drugs, heparin infusion Complex cardiac surgery Patient with liver dysfunction or pre-existing coagulation disorders Patients who are not fulfilling the criteria of ANH

Design outcomes

Primary

MeasureTime frame
To compare ROTEM coagulation parameter (INTEM-CT) in patients with and without acute normovolumic haemodilutionTimepoint: T1: baseline value 10 min after induction and before ANH in both groups T2: 40 minute after induction (after ANH) T3: 5 min after protamine administration T4: 35 min after protamine administration (ANH re-transfusion)—

Secondary

MeasureTime frame
To Quantify the changes in ROTEM coagulation parameter, Changes in Hct and electrolyte level (Na, K, HCO3, Ca, lactate, serum osmolarity), Chest tube drain output in first 24 hours, Number of Allogenic blood and blood products transfusion in first 24 hours postoperative period, re-exploration rate, pulmonary complications (reintubation, pneumonia), myocardial ischemia, acute renal failure, all-cause mortality at 30 days in both groups Timepoint: T1: baseline value 10 min after induction and before ANH in both groups T2: 40 minute after induction (after ANH) T3: 5 min after protamine administration T4: 35 min after protamine administration (ANH re-transfusion)—

Countries

India

Contacts

Public ContactArun Sahaya Raja M

AIIMS Jodhpur

geetamanoj007@yahoo.co.in9414084584

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026