Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: Use of Helmet interfaced of Non invasive ventilation.: After randomization, all patients with diagnosed corona virus infection fulfilling the inclusion criteria shall be given respirato
Sponsors
AIIMS Patna
Eligibility
Inclusion criteria
Inclusion criteria: Patients diagnosed with corona virus infection presenting with all of the following. a. A ratio of partial pressure of oxygen (PaO2) to (FiO2) below 300. b. PaCO2 less than 45 mmHg as well as c. Respiratory rate greater than 25/ minute
Exclusion criteria
Exclusion criteria: 1. cardiogenic pulmonary edema, 2. severe neutropenia, 3. hemodynamic instability, 4. Use of vasopressors, 5. Glasgow Coma Scale score of 12 points or less 6. loss of protective gag reflex 7. urgent need for intubation 8. presence of metabolic acidosis with arterial blood pH 9. History of any underlying chronic lung disease.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| To compare time to intubation ie hours from time of initiation of intervention until intubation.Timepoint: From time of initiation of intervention to time of intubation.;To assess intubation-free daysTimepoint: From the time of randomization to a maximum of 28 days after randomization.;To compare rates of mortality or discharge from hospital.Timepoint: At time of mortality or discharge from hospital, upto a maximum of 28 days after randomization.;To compare PaO2/FiO2 ratio, PaCO2 and PH changes after 24 hrs, and 48 hrs of therapyTimepoint: 24 hours and 48 hours after initiation of either therapy. | — |
Primary
| Measure | Time frame |
|---|---|
| To compare rate of intubations in patients getting high flow nasal oxygen (HFNO) versus helmet interface NIV for management of Covid patients.Timepoint: Intubation at any time during hospital stay up to a maximum of 28 days shall be assessed. | — |
Countries
India
Contacts
Public ContactNISHANT SAHAY
AIIMS Patna
Outcome results
None listed