What is better for patients with chronic knee osteoarthritis?Ultrasound Guided Genicular Nerve Block using 0.5% bupivacaine in Combination with Intra-Articular Platelet Rich Plasma Protein or Intra-Articular Steroids ?

Comparison of Ultrasound Guided Genicular Nerve Block using 0.5% bupivacaine in Combination with Intra-Articular Platelet Rich Plasma Protein and Intra-Articular Steroids among Patients with Chronic Knee Osteoarthritis â?? A Triple Blinded Randomized Clinical Trial

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/12/029705

Enrollment

Registered

2020-12-10

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 8- Other Procedures

Interventions

Intervention1: 0.5% bupivacaine in Combination with Intra-Articular Platelet Rich Plasma Protein: Single dose of 0.5% bupivacaine in Combination with Intra-Articular Platelet Rich Plasma Protein is ad

Eligibility

Inclusion criteria

Inclusion criteria: Subjects aged 50â??80 years with knee pain of moderate or greater intensity on most or all days for >= 3 months and radiological tibiofemoral OA (Kellgren-Lawrence grade 2â??4 as evaluated by a radiologist).

Exclusion criteria

Exclusion criteria: 1. Subjects with acute knee pain 2. Subjects who underwent prior knee surgery or electropuncture treatment 3. Subjects with other connective tissue diseases that affected the knee, serious neurological or psychiatric disorders 4. Subjects under steroid or hyaluronic acid injection therapy during the previous 3 months 5. Subjects with sciatic pain, anticoagulant medication use and pacemaker use

Design outcomes

Primary

Measure	Time frame
Pain using Visual Analog Scale (VAS) Timepoint: 1, 2, 4, and 8 weeks	—

Secondary

Measure	Time frame
Functional changes in the knee using Oxford Knee Scores (OKS) Patient satisfaction with treatment using Global Perceived Effects and Incidence of adverse effects.Timepoint: 1, 2, 4, and 8 weeks	—

Countries

India

Contacts

Public ContactSivabalakumaran Kengadaran

Department of Anesthesiology, Chengalpattu Government Medical College

statzwizz@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026