Health Condition 1: N72- Inflammatory disease of cervix uteri
Conditions
Interventions
None listed
Sponsors
Manipal College of Health Professions
Eligibility
Inclusion criteria
Inclusion criteria: For healthy controls: 1 Negative for intraepithelial lesion For premalignant lesions: 1 Women above 25 to 65 years attending the department of OBG at Kasturba Hospital, Manipal undergoing Pap smear testing 2 Epithelial cell abnormality ââ?¬â?? Squamous cells which include ASC-US Squamous cells (Atypical squamous cells of uncertain significance), ASC-H (Atypical squamous cells ââ?¬â?? HSIL cannot be excluded), LSIL (Low grade squamous intraepithelial lesion), HSIL (High grade squamous intraepithelial lesion) - Moderate dysplasia (CIN-II), Severe dysplasia (CIN- III) For malignant lesions: 1 Women with clinically diagnosed carcinoma of cervix attending Radiotherapy and Oncology department.
Exclusion criteria
Exclusion criteria: For healthy controls: � NILM without any infection or reactive changes For premalignant lesions � Heavy discharge and infections � Menstruation � History of CC � Atypical Glandular cells on Pap test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Performance of Serpin B3 and LRG1 mRNA expression for the early prediction of cervical malignant lesionTimepoint: At baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| - Association of HPV DNA (16 and 18) with alteration in microbiota of cervix - Reliability of automated pap smear reports with predictive values Timepoint: 4 years | — |
Countries
India
Contacts
Public ContactReshma Maria Cocess Dsouza
Manipal College of Health Profssions
Outcome results
None listed