Role of vitamin c in diffuse axonal injury patients in icu

Role of vitamin c in critically ill traumatic brain injury patients

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/12/029688

Enrollment

Registered

2020-12-09

Start date

Unknown

Completion date

Unknown

Last updated

2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G968- Other specified disorders of central nervous system

Interventions

Intervention1: Nil: Nil Intervention2: ROLE OF VITAMIN C IN CRITICALLY ILL TRAUMATIC BRAIN INJURY PATIENTS: Patients will be allocated to following 3 groups randomly with 20 patients in each group. G

Eligibility

Inclusion criteria

Inclusion criteria: Patient’s age > 18 years and < 65 years with mild to moderate head injury as defined by a Glasgow come scale of 9-14 with radiological diagnosis of diffuse axonal injury.

Exclusion criteria

Exclusion criteria: 1.Patient refusal 2.Liver or renal disease 3.Glucose 6 phosphate dehydrogenase deficiency 4.Previous CNS pathology ( eg stroke ,head injury or previous craniotomy) 5.Space occupying lesions and those with pre-resuscitation shock and hypoxic ischaemic encephalopathy

Design outcomes

Primary

Measure	Time frame
No of ventilator free days and length of icu stayTimepoint: From 1st day of extubation or decannulation to shifting the patient to ward and total number of days the patient stayed in icu including the treatment	—

Secondary

Measure	Time frame
Effect on mortality and infection reduction in traumatic brain injury patientsTimepoint: Depending on the length of icu stay and vitamin c iv duration	—

Countries

India

Contacts

Public ContactDr Ghanshyam Yadav

Banaras Hindu university

ghanshyambhu1976@gmail.com9838894169

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026